M. lignano Neoblast Screen 2016 Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano. (2016) Grudniewska M*, Mouton S*, Simanov S, Beltman F, Grelling M, de Mulder K, Arindrarto W, Weissert P, van der Elst S, Berezikov E. eLife 2016;5:e20607. Home Download

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Transcript classification

Neoblast, stringent 357 transcrip clusters obtained by overllaping 'Irradiation' and 'Neoblast' categories
Neoblast 924 transcript clusters enriched in proliferating cells excluding germline
S/G2/M, no gonads 956 transcript clusters enriched in late-S/G2/M cells in all conditions, including intact animals, cut heads and juveniles
Germline 2,739 transcripts enriched in proliferating germline cells
Int S/G2/M 7,124 transcript clusters significantly enriched in late-S/G2/M cells of intact animals
Irradiation 7,277 transcript clusters significantly depleted at all three time points after irradiation (0h vs 12h, 0h vs 24h, 0h vs 72h)

Irradiation timecourse

FACS-based analysis

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